To analyze the impact of IKK2 inhibitor VIII (HY-13060, Medchem Specific, Monmouth Junction, NJ) on OA advancement, MLI surgeries were executed in 12-week-aged C57BL/6 WT mice. The mice ended up injected with IKK2 inhibitor VIII (two?mg/kg, IP) every single alternate working day for 5 months. OARSI scoring was performed by blinded reviewer based up